Download e-book for kindle: Biomolecular Networks: Methods and Applications in Systems by Luonan Chen;Rui-Sheng Wang;Xiang-Sun Zhang


By Luonan Chen;Rui-Sheng Wang;Xiang-Sun Zhang

ISBN-10: 0470243732

ISBN-13: 9780470243732

Substitute options and instruments for examining biomolecular networksWith the new swift advances in molecular biology, high-throughput experimental equipment have led to huge, immense quantities of knowledge that may be used to review biomolecular networks in residing organisms. With this improvement has come acceptance of the truth that a classy dwelling organism can't be totally understood via in basic terms studying person elements. quite, it's the interactions of parts or biomolecular networks which are finally chargeable for an organism's shape and serve as. This publication addresses the $64000 desire for a brand new set of computational instruments to bare crucial organic mechanisms from a platforms biology approach.Readers gets finished insurance of studying biomolecular networks in mobile platforms in response to on hand experimental info with an emphasis at the elements of community, method, integration, and engineering. every one subject is handled extensive with particular organic difficulties and novel computational methods:GENE NETWORKS—Transcriptional law; reconstruction of gene regulatory networks; and inference of transcriptional regulatory networksPROTEIN interplay NETWORKS—Prediction of protein-protein interactions; topological constitution of biomolecular networks; alignment of biomolecular networks; and network-based prediction of protein functionMETABOLIC NETWORKS AND SIGNALING NETWORKS—Analysis, reconstruction, and purposes of metabolic networks; modeling and inference of signaling networks; and different subject matters and new trendsIn addition to theoretical effects and strategies, many computational software program instruments are referenced and on hand from the authors' sites. Biomolecular Networks is an quintessential reference for researchers and graduate scholars in bioinformatics, computational biology, structures biology, desktop technological know-how, and utilized arithmetic.

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Additional info for Biomolecular Networks: Methods and Applications in Systems Biology (Wiley Series in Bioinformatics)

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2 BIOMOLECULAR NETWORKS IN CELLS Through the transcription and translation processes, gene products such as mRNA and protein are produced. Gene, mRNA, and protein are known as biological molecules or basic components. The complicated relations and interactions between these components are responsible for diverse cellular functions. 2 BIOMOLECULAR NETWORKS IN CELLS 9 or inhibit the transcription of genes to synthesize mRNAs by regulating the activities of genes. Since these TFs themselves are products of genes, the ultimate effect is that genes regulate each other’s expression as part of a transcription (or transcriptional) regulatory network (TRN) or gene regulatory network (GRN).

Then, both biochemical reactions and transcription regulations including protein – DNA interactions trigger the expression of some genes to respond the signals [Alb05]. In short, although cells consist of various biological molecules, their cellular processes and functions are actually achieved by biomolecular networks with the collaborative effects of those individual components. 7(b) illustrates several typical molecular networks at different levels in cellular systems, which are the backbone of network systems biology.

Except for the main characteristics of systems biology, sophisticated computational and analytical methods are definitely indispensable as tools of network systems biology. For instance, reverse-engineering gene regulatory networks requires optimization models to fit time-series experimental data. Mining useful knowledge from the topological properties of biomolecular networks cannot be done without machine learning and data-mining methods. Dealing with noise and uncertainty underlying experimental data demands appropriate probabilistic or statistical methods.

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Biomolecular Networks: Methods and Applications in Systems Biology (Wiley Series in Bioinformatics) by Luonan Chen;Rui-Sheng Wang;Xiang-Sun Zhang

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